LGD 4033 is alleged to be one of the most potent SARMs on the current market. This product is mainly used by individuals who are seeking appearance enhancement and bodybuilders. LGD 4033 is also referred to as Anabolicum or Ligandrol. It has been proven to be effective in improving the recovery process from hip fractures.
An Overview of LGD 4033
This compound is relatively new, but it has attracted the attention of the medical community and other people seeking appearance enhancement and physical performance. Scientists have been exploring the different types of SARMS that can be used to overcome bone diseases and muscle wasting. Bodybuilders are also looking for healthier, safer alternatives to steroids. Its users claim that it is more potent than MK-2866.
Both of these products are safe for use since it doesn’t cause any severe side effects. Again they don’t cause any harm to the vital organs. Like all SRMS, ligandrol work by binding itself to the androgen receptors found in the bones and muscles with high selectivity and affinity. This means that it does not affect the functioning of the vital organs like sebaceous gland and prostate or suppress the production of testosterone hormone.
- Few side effects
- Fat loss
- Increases strength
- May help strengthen and heal bones
- Its usage is not allowed in professional sports
- Can slightly suppress testosterone
- Its long-term effects are not known
How Does Ligandrol Work?
This product is known for increasing anabolic activities in the bones and muscles while reducing bone breakdown and muscle wasting. Ongoing clinical trials have proven that LGD is beneficial in increasing strength and lean body mass, improving well-being, decreasing body fat as well as enhancing the healing process.
- The only issue with LGD is that the goal and doses of clinical trials are different from real-world use. Initially, both LGD-4033 and Mk-2866 were developed to help cancerous patients and reducing muscle wasting that affects individuals with muscular dystrophy. Having realized that these products are effective in enhancing healing and increasing bone strength, scientist began the process of finding if they are capable of improving bone diseases like osteoporosis.
- Initially, LGD 4033 was developed by Ligand Pharmaceuticals, but Therapeutics Company later took over research. This is the firm that renamed this product to VK5211. More research is being conducted to examine the effectiveness of this product in enhancing hip fracture recovery.
- LGD 4033 has been in use in the bodybuilding community for some years although more research is still being conducted. It is classified as a bodybuilding supplement, just like the other SARMs. Professional athletes should avoid taking this supplement since the World Anti-Doping Agency has banned it. Despite this, its users claim that it is one of the most potent SARMs on the current market.
It’s Mechanism of Action
Most SARMs are selective to bones and muscles since:
- Bones and muscles have individual sensors for them known as coregulators.
- Are capable of navigating the bones and muscles to a great extent.
- Can activate the bone receptors even if they are chemically different from the conventional steroids.
- Being nonsteroidal, most SARMS aren’t ’substrates for CYP19 aromatase or 5 alpha–reductase. This means that they can’t be converted to estrogen or testosterone metabolite DHT.
It is worth to note that all SARS are not muscle selective. Some of them have been abandoned for causing severe side effects. Furthermore, some of them are used as potential birth control pills.
Primary Benefits of LGD 4033
Most athletes and bodybuilder are impressed by the numerous health benefits of this supplement. They include;
- Injury repair
- Great endurance
- Increased muscle mass
- Increase in strength
- Loss of body fat
- Faster recovery
An increase in muscle mass occurs when the muscle’s androgen receptors are selectively activated. Activation of the bone tissues receptors is known for facilitating the recovery process from injuries.
Let’s have a look at the potential benefits of LGD 4033 in details;
Osteoporosis and Fractures
- Increasing bone formation and preventing bone loss helps prevent osteoporosis. Scientists are looking for a safe option for bone healing and increasing bone strength. Some of the prescription drugs used to inhibit bone-degrading come with specific side effects that most patients can’t tolerate.
- Synthetic hormones used in hormone replacement therapy are known for increasing the risks of heart diseases, uterine lining, and breast cancer.
- As mentioned earlier, SARMs work by selectively activating the androgen receptors. This, in turn, increases the bone formation process as well as boosting bone mineral density. The androgen receptors play an essential role in maintaining bone mass, thereby facilitating the healing of bone fractures.
Libido and The brain
- More research is still being conducted to find out the effect of LGD 4033 on the brain. Testosterone is known for having a massive impact on cognitive and on psychosexual behavior. Being selective to the muscle and bone, SARMS can also cross into one’s brain.
- This is why they have a positive effect on mood enhancement libido. Some people believe that effect if SARMs on the brain is attributed to the increase in stamina and muscle strength. Viking Therapeutics states that this supplement is effective in improving energy, libido, and cognition.
- Muscle wasting is one of the main problems affecting cancer patients. This is a problem that can negatively affect the quality of life of the affected persons, their survival, and chemotherapy tolerance. SARMs are beneficial in improving fitness and muscle mass in both cancer patients and healthy people.
- SRAMS work by targeting the anabolic pathways targeted by typical steroids without causing androgenic effects. The dose varies depending on the desired results, but it does not cause any detrimental effects ones, hair, skin, or prostate.
Contraception for Men
- Male contraceptive pills are either limited, or they don’t exist in the market. Research has shown that SARMs don’t cause hormonal changes like other contractive pills. Again they have a positive effect on one’s libido.
- Cachexia involves extreme muscle atrophy, appetite loss, fatigue, and weight loss. This issue is common in patients suffering from kidney diseases, severe burns, cancer, HIV/AIDS, and sepsis.
- It is mainly caused by high levels of cytokine (IFN gamma, IFN 1b, TNFα). Muscle wasting is one of the leading causes of cancer-related deaths. Scientists have unearthed the benefits of SARMS in improving lean body muscles, bone density, and cachexia.
However, these products have a significant drawback since they are known for causing severe side effects on the vital body organs like liver, i.e., liver toxicity. SRAMS are capable of increasing the muscle mass without affecting the hematocrit or prostate. Increasing muscle mass is a practical way of increasing the survival rate of patients with cachexia.
It is reported that most users take the same dosage for bulking, cutting, as well as body recomposition cycles. The recommended daily dosage is 10 mg and 5 mg for men and women, respectively. However, some athletes take high doses of 20mg/day, but this is not recommended.
How Long Can Ligandrol Stay In The Body System?
The half-life of this supplement is about 24-36 hours. This means that its level will decrease by 50% within a day and by 75 percent within two days. Its levels will be undetectable by the fourth day.
Side Effects Associated with LGD 4033
Clinical trials have shown that this supplement does not have any severe side effects on the user’s body or mind. Some of the common effects of Ligandrol include;
- Dry mouth
- Respiratory tract infections
- Muscle pain
From the ongoing clinical trials, it can be concluded that LGD 4033 is safer than the other types of bodybuilding doses.
Reported Gains and Users Review
Many professionals and athletes who are looking for bodybuilding supplements prefer take LGD 4033 as their preferred choice. Most users, including those taking high bodybuilding doses, report that they have not experienced any significant side effects. Some of the positive user’s reports include;
- Less pain
- Easier fat loss
- Increased libido and stamina
- Amazing pumps
- No liver damage
- Much strength as compared to Ostarine
- Quick recovery
- No changes in blood pressure or cholesterol
- Increased cardiovascular strength and lifting
Some of the common effects reported include;
- Mild testosterone suppression
- Mild gyno
- Some water retention
Where to Buy LGD 4033
Many online vendors sell this Ligandrol in The US. Buyers can get a high-quality and tested product by buying from trustworthy sellers. Its users are advised to consult healthcare professionals before taking this supplement.